Vemurafenib oral tablets
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Vemurafenib oral tablets
What is this medicine?
VEMURAFENIB (Vem ue RAF e nib) is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat melanoma, a type of skin cancer, and Erdheim-Chester disease.
How should I use this medicine?
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush or chew this medicine. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice. Take doses approximately 12 hours apart.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
breathing problems
changes in vision
dark urine
eye pain or swelling
fast or irregular heartbeat
feeling faint or lightheaded, falls
general ill feeling or flu-like symptoms
light-colored stools
loss of appetite
new wart; skin sore or reddish bump that bleeds or does not heal; change in size or color of a mole
pain, tingling, numbness in the hands or feet
rash, fever, and swollen lymph nodes
redness, blistering, peeling or loosening of the skin, including inside the mouth
right upper belly pain
sensitivity to sunlight or sunburn
thickening of the palms of your hands or soles of your feet
tightening of the fingers inward
unusually weak or tired
vomiting
yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
changes in taste
decreased appetite
diarrhea
dizziness
dry skin
hair loss
headache
joint pain
muscle pain
nausea
swelling of the ankles, feet, hands
tired
What may interact with this medicine?
Do not take this medicine with any of the following medications:
cisapride
dronedarone
fluconazole
pimozide
posaconazole
saquinavir
thioridazine
This medicine may also interact with the following medications:
antiviral medicines for HIV or AIDS
caffeine
certain antibiotics like clarithromycin, erythromycin, telithromycin
certain medicines for fungal infections like itraconazole, ketoconazole, voriconazole
certain medicines for irregular heart beat
certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
certain medicines that treat or prevent blood clots like warfarin
dextromethorphan
digoxin
nefazodone
midazolam
other medicines that prolong the QT interval (cause an abnormal heart rhythm) like dofetilide, ziprasidone
rifabutin
rifampin
rifapentine
St. John's wort, Hypericum perforatum
tizanidine
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is less than 4 hours until your next scheduled dose, do not make up for the missed dose and just take your next dose at your regular time. Do not take double or extra doses.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep this medicine in the original container. Keep tightly closed. Throw away any unused medicine after the expiration date.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
eye disease, vision problems
heart disease
history of irregular heartbeat
history of low levels of calcium, magnesium, or potassium in the blood
kidney disease
liver disease
recent or ongoing radiation therapy
an unusual or allergic reaction to vemurafenib, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
What should I watch for while using this medicine?
Visit your doctor for regular check ups. You will need to have blood work while you are taking this medicine.
This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your health care provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.
Talk to your doctor about your risk of cancer. You may be more at risk for certain types of cancers if you take this medicine.
Tell your doctor or health care provider right away if you have any change in your eyesight.
This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.
Do not become pregnant while taking this medicine and for 2 weeks after your last dose. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is potential for serious side effects to an unborn child. Talk to your health care provider or pharmacist for more information. Do not breast-feed an infant while taking this medicine and for 2 weeks after your last dose.
Updated:  
November 22, 2020