Tenecteplase, TNK-tPA
Tenecteplase Solution for injection
What is this medicine?
TENECTEPLASE (TEN neck te place) is used to dissolve blood clots that form in certain blood vessels. This medicine is used when a blood clot in a heart artery causes a heart attack.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
aneurysm
bleeding problems or problems with blood clotting
diabetic retinopathy or bleeding problems of the eye
endocarditis (infection of the heart valves)
head injury, brain disease, or tumor
high blood pressure
infection
irregular heartbeats
kidney disease
liver disease
mitral stenosis
recent biopsy, childbirth, surgery, or trauma (injury)
recent history of stroke
stomach ulcer or bleeding ulcer
an unusual or allergic reaction to tenecteplase, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
How should I use this medicine?
This medicine is for injection into a vein. It is given by a health care professional in a hospital or clinic setting.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
This does not apply.
What may interact with this medicine?
Do not take this medicine with any of the following medications:
aminocaproic acid
aprotinin
tranexamic acid
This medicine may also interact with the following medications:
antiplatelet drugs such as ticlopidine or clopidogrel
aspirin and aspirin-like drugs
medicines that treat or prevent blood clots like warfarin, heparin, enoxaparin, and dalteparin
NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
You will be closely monitored to check your progress after you receive this medicine. Follow the advice of your doctor or health care professional exactly. You may need bed rest to minimize the risk of bleeding.
This medicine can make you bleed more easily. This effect can last for several days. Try to avoid damage to your teeth and gums when you brush or floss your teeth, and to avoid any other injury to yourself.
Do not take aspirin, ibuprofen, or other nonprescription pain relievers during or for several days after this medicine unless otherwise instructed by your doctor or health care professional.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
signs and symptoms of bleeding such as bloody or black, tarry stools; red or dark-brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eye, gums, or nose
signs and symptoms of a stroke such as changes in vision; confusion; trouble speaking or understanding; severe headaches; sudden numbness or weakness of the face, arm, or leg; trouble walking, dizziness, loss of balance or coordination
slow or fast heart rate
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
dizziness
fever
nausea, vomiting
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
This drug is given in a hospital or clinic and will not be stored at home.
Updated:  
March 21, 2017
Sources:  
U.S. FDA-approved Package Insert