Doxylamine; Pyridoxine Delayed- and Extended-Release Oral Tablets
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Doxylamine; Pyridoxine Delayed- and Extended-Release Oral Tablets
What is this medicine?
Doxylamine; pyridoxine (dox IL a meen; peer i DOX een) is a combination of an antihistamine and vitamin B6. The drug is used to treat nausea and vomiting associated with pregnancy.
How should I use this medicine?
Take this medicine by mouth with a glass of water. Do not cut, crush or chew this medicine. Follow the directions on the package or prescription label. Take this medicine on an empty stomach. Take your medicine at regular intervals. Do not take it more often than directed.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
changes in vision
confused, agitated, or nervous
fast, irregular heartbeat
feeling faint or lightheaded, falls
muscle or facial twitches
seizure
trouble passing urine or change in the amount of urine
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
dry mouth
headache
loss of appetite
stomach upset
What may interact with this medicine?
alcohol
atropine
antihistamines for allergy, cough and cold
certain medicines for bladder problems like oxybutynin, tolterodine
certain medicines for stomach problems like dicyclomine, hyoscyamine
certain medicines for travel sickness like scopolamine
certain medicines for Parkinson's disease like benztropine, trihexyphenidyl
ipratropium
MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep bottle tightly closed and protect from moisture. Do not remove desiccant canister from bottle. Throw away any unused medicine after the expiration date.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
contact lenses
glaucoma
liver disease
lung or breathing disease, like asthma or emphysema
pain or trouble passing urine
prostate trouble
ulcers or other stomach problems
an unusual or allergic reaction to doxylamine or pyridoxine (vitamin B6), other medicines, foods, dyes, or preservatives
breast-feeding
What should I watch for while using this medicine?
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. See your doctor right away if you get a high fever or have problems breathing.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.
This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye doctor if the problem does not go away or is severe.
This medicine may cause false positive urine tests for certain medicines like methadone, opiates, and PCP.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.
Updated:  
October 09, 2020