Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir oral tablets
Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir oral tablets
What is this medicine?
DASABUVIR; OMBITASVIR; PARITAPREVIR; RITONAVIR (da sa' bue vir; om bit' as vir; par'' i ta' pre vir; ri toe' na veer) is a combination of four medicines. It is used to treat hepatitis C. It will not work for colds, flu, or other viral infections.
How should I use this medicine?
Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Take this medicine with food. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think you are better. Do not skip doses or stop your medicine early.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
signs and symptoms of high blood sugar such as being more thirsty or hungry or having to urinate more than normal. You may also feel very tired or have blurry vision.
signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; confusion; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
itching
nausea
rash
trouble sleeping
What may interact with this medicine?
Do not take this medicine with the following medication:
alfuzosin
alcohol
apalutamide
atorvastatin
carbamazepine
cisapride
colchicine
dronedarone
efavirenz
ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
everolimus
female hormones, like estrogens and birth control pills, patches, rings, or injections
gemfibrozil
lomitapide
lovastatin
lumacaftor; ivacaftor
lurasidone
midazolam
naloxegol
phenytoin
phenobarbital
pimozide
ranolazine
rifampin
sildenafil
simvastatin
sirolimus
St. John's wort (Hypericum perforatum)
tacrolimus
triazolam
This medicine may also interact with the following medications:
acetaminophen; hydrocodone
alprazolam
amlodipine
antiviral medicines for HIV or AIDS
buprenorphine/naloxone
candesartan
carisoprodol
certain medicines for diabetes
certain medicines for irregular heart beat like amiodarone, bepridil, diltiazem, disopyramide, flecainide, lidocaine, mexiletine, propafenone, quinidine
cyclobenzaprine
cyclosporine
diazepam
fluticasone
furosemide
ketoconazole
losartan
metformin
nifedipine
omeprazole
pravastatin
quetiapine
rosuvastatin
salmeterol
valsartan
verapamil
voriconazole
warfarin
What if I miss a dose?
If you miss a dose, take it as soon as you can. If your next dose of ombitasvir, paitaprevir, ritonavir is to be taken in less than 12 hours, then do not take the missed dose. If your next dose of dasabuvir is to be taken in less than 6 hours, then do not take the missed dose. Take the next dose at your regular time. Do not take double or extra doses.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature below 30 degrees C (86 degrees F). Throw away any unused medicine after the expiration date.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
diabetes
HIV or AIDS
other liver disease
an unusual or allergic reaction to dasabuvir, ombitasvir, paritaprevir, ritonavir, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
What should I watch for while using this medicine?
See your doctor or healthcare provider for a follow-up visit as directed. You may need blood work while you are taking this medicine. Tell your doctor if your symptoms do not improve or if they get worse.
If you have had hepatitis B infection (HBV) in the past, taking this medicine could cause the HBV to become active again. If you have had HBV, your doctor should monitor you with blood tests. Tell your doctor right away if you develop a general ill feeling, light-colored stools, loss of appetite, unusual weakness, or yellowing of the eyes or skin.
This medicine may increase blood sugar. Ask your healthcare provider if changes in diet or medicines are needed if you have diabetes.
Updated:  
March 13, 2020