There are 2 types of chromosomes:

• Sex chromosomes, which determine male or female gender

• Autosomes, which are all of the other chromosomes (chromosome pairs 1 through 22) or non-sex chromosomes

Autosomal inheritance of a gene means that the gene is located on one of the autosomes. This means that males and females are equally likely to inherit the gene. "Dominant" means that a single copy of the gene can cause a particular trait, such as brown eyes instead of blue eyes. When a parent has a dominant gene, there is at least a 50% chance that any child he or she has will also have the trait.

There are 4 possible combinations in the children. These combinations are possible every time a pregnancy occurs between these 2 individuals. The gender of the children (whether they are sons or daughters) does not matter. The chance is 50/50 for them to inherit the autosomal genes.

A characteristic of some dominant genes is that they can have variable expression. This means that some people have milder or more intense characteristics than others. Another important characteristic of dominant genes is that in some cases, they can have reduced penetrance. This means that sometimes a person can have a dominant gene copy but not show any signs of the gene. The concept of reduced penetrance is particularly important in the case of autosomal dominant cancer susceptibility genes. If a person has inherited a cancer susceptibility gene, it does not mean he or she will automatically develop cancer. It simply means that the person has inherited a mutation in a gene that gives him or her a higher chance to develop cancer than someone without the mutation.

Examples of conditions involving autosomal dominant inheritance are: 

• Marfan syndrome 

• Ehlers-Danlos syndrome 

• Neurofibromatosis 

• Achondroplasia